suPAR and Team Nephrology

suPAR and Team Nephrology

Primary focal segmental glomerulosclerosis (FSGS) accounts for nearly 10 % of patients who require renal replacement therapy. Elevated circulating levels of soluble urokinase receptor (suPAR) have been identified as a biomarker to discriminate primary FSGS from other glomerulopathies. Subsequent reports have questioned the diagnostic utility of this test. In a study in BMC Medicine, Huang et al...

suPAR: The Molecular Crystal Ball

soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that full-length suPAR is a regulator of uPAR/uPA by actingas uPA-scavenger, whereas...

Nephrology nurses in a new role: diagnostic and interventional nephrology.

Diagnostic and interventional nephrology is a growing subspecialty of nephrology. Increasingly, procedural care of nephrology patients is being managed by nephrologists trained in this area. As a result, new opportunities have been created for nephrology nurses as they assist these interventionists in the administration of care in diagnostic and interventional nephrology. This article describes...

Nephrology, Transplantation and Shunts

Nephrology, dialysis and transplantation.

This review highlights some of the more important advances that have been made in renal physiology, nephrology and renal replacement therapy. There have been dramatic advances in our understanding of the molecular mechanisms in physiology, pathology and in the pharmacology ofimmunosuppression. We understand better the factors that lead to the relentless progression to end stage renal failure in...